Sinusoidal endothelial cells direct traffic at the intersection of regeneration and fibrosis
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چکیده
منابع مشابه
Liver sinusoidal endothelial cells and liver regeneration.
Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic stellate cell, but after liver injury, HGF expression has been thought to increase markedly in proliferating LSECs. However, emerging data suggest that even after injury, LSEC expression of HGF does not increase ...
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The normal liver is characterized by immunologic tolerance. Primary mediators of hepatic immune tolerance are liver sinusoidal endothelial cells (LSECs). LSECs block adaptive immunogenic responses to Ag and induce the generation of T regulatory cells. Hepatic fibrosis is characterized by both intense intrahepatic inflammation and altered hepatic immunity. We postulated that, in liver fibrosis, ...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2014
ISSN: 0270-9139
DOI: 10.1002/hep.27116